Targeted therapy for squamous cell carcinoma of the head and neck.
نویسندگان
چکیده
Targeted agents have emerged as novel drugs in the oncology field based on our understanding of the biology of individual malignancies, and have had a promising impact in several tumors. Squamous cell carcinoma of the head and neck (SCCHN) is a common disease with little progress made in survival over the past few decades. SCCHN is characterized by overexpression of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF), both of which appear to have a prognostic value. Hence these receptors and their downstream pathways make attractive therapeutic targets. This review discusses targeted therapies currently being evaluated for their role in squamous cell carcinoma of the head and neck.
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عنوان ژورنال:
- Journal of the Egyptian National Cancer Institute
دوره 21 2 شماره
صفحات -
تاریخ انتشار 2009